RGS6 (NM_001204417) Human Untagged Clone
CAT#: SC331577
RGS6 (untagged) - Homo sapiens regulator of G-protein signaling 6 (RGS6), transcript variant 3
"NM_001204417" in other vectors (2)
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Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Symbol | RGS6 |
Synonyms | GAP; HA117; S914 |
Vector | pCMV6 series |
Sequence Data |
>NCBI ORF sequence for NM_001204417, the custom clone sequence may differ by one or more nucleotides
ATGGCTCAAGGATCCGGGGATCAAAGAGCAGTGGGGGTTGCTGACCCAGAGGAGAGTTCTCCAAACATGA TCGTTTACTGCAAAATTGAAGACATCATTACAAAGATGCAAGATGACAAGACAGGGGGTGTGCCCATCAG AACAGTCAAGAGCTTTCTCTCCAAAATCCCCAGTGTCGTCACAGGTACTGACATTGTGCAGTGGCTTATG AAGAACCTTTCCATTGAGGACCCAGTTGAAGCAATACACTTGGGGAGCCTTATCGCTGCCCAGGGCTACA TCTTTCCAATCTCAGACCATGTTCTCACCATGAAGGATGATGGCACCTTTTATCGTTTCCAGGCTCCGTA CTTCTGGCCTTCGAACTGCTGGGAACCTGAAAACACTGACTATGCCATCTATCTCTGTAAGAGGACAATG CAAAATAAAGCAAGGCTGGAACTGGCAGATTATGAAGCAGAAAACTTAGCAAGACTCCAGAGGGCCTTTG CGAGGAAGTGGGAATTCATCTTTATGCAAGCAGAAGCACAAGTAAAGATTGACCGGAAAAAAGACAAGAC AGAAAGGAAAATTTTGGATAGTCAAGAACGAGCCTTTTGGGATGTCCACAGGCCTGTGCCAGGCTGTGTG AACACAACAGAAATGGATATCCGAAAATGTCGACGTTTGAAGAATCCACAAAAGGTTAAAAAGTCCGTGT ATGGCGTGACTGAAGAGTCCCAGGCACAGAGCCCGGTGCATGTACTCAGCCAACCAATCAGGAAAACAAC AAAAGAGGACATCCGGAAACAGATAACATTTTTGAACGCACAGATCGACAGACATTGTTTGAAAATGTCC AAAGTGGCTGAAAGTTTAATTGCCTACACGGAACAATATGTGGAATATGACCCTTTGATAACACCAGCTG AGCCATCCAACCCTTGGATCAGCGATGACGTTGCTTTGTGGGACATAGAGATGAGCAAAGAGCCCAGCCA ACAGCGAGTAAAAAGATGGGGCTTCTCTTTCGATGAGATATTGAAGGACCAGGTGGGGCGGGACCAGTTT CTACGATTCCTGGAGTCCGAATTCAGTTCAGAAAACCTCAGGTTCTGGCTGGCTGTCCAAGATCTTAAGA AACAACCCCTACAGGATGTGGCCAAGAGGGTAGAAGAAATCTGGCAAGAGTTTCTGGCTCCAGGGGCTCC AAGTGCAATCAACCTGGATTCTCACAGCTATGAGATAACCAGTCAAAATGTCAAAGATGGAGGGAGATAT ACATTTGAAGACGCCCAGGAGCACATCTACAAGCTGATGAAGAGTGACAGCTATGCCCGCTTCCTCCGGT CAAATGCTTACCAGGATTTGCTGCTGGCCAAGAAGAAGCCAGAAAGTGAGCAAGGTCGTAGAACTTCCCT AGAAAAGTTCACTCGCAGTGTGTTGTATTCCAACACTCCACTCGCTAAGAGGCCCTGA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001204417 |
ORF Size | 1458 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Reference Data | |
RefSeq | NM_001204417.1, NP_001191346.1 |
RefSeq Size | 1716 |
RefSeq ORF | 1458 |
Locus ID | 9628 |
Protein Families | Druggable Genome |
Gene Summary | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Mar 2011] Transcript Variant: This variant (3) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3, also known as RGS6Lbeta1) with a distinct C-terminus compared to isoform 1. |
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