SETMAR (NM_001243723) Human Untagged Clone

CAT#: SC332016

SETMAR (untagged) - Homo sapiens SET domain and mariner transposase fusion gene (SETMAR), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SETMAR
• Synonyms: Mar1; METNASE
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001243723, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTTCGCGGAAGCGGCAAAGACGACACGGCCTTGTGGGATGGCGGAGTTTAAGGAGAAGCCTGAGGCCC
  CGACTGAGCAGCTGGATGTCGCGTGCGGCCAGGAAAACTTGCCGGTGGGCGCGTGGCCCCCGGGGGCCGC
  GCCGGCGCCCTTCCAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATA
  ACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAG
  AGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGA
  ATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCAC
  TTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGTT
  CTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTC
  AGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAG
  CAAATTCGAGCAATTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCA
  ACAATGCATTTGGCCCAGGAACTGCTAACGAACGTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGG
  AGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATCAGAAGTTGACAACGACCAGTTGAGAGCA
  ATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCATTCTACGG
  TCGTTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGA
  AAATCAAAAAAATCGTCGTTTTGAAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTC
  GATCGGATTGTGACGTGTGATGAAAAGTGGATTTTATATGACAACCGGCGACGATCAGCTCAGTGGTTGG
  ATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAAGGTCATGGTCACTATTTG
  GTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTAT
  GCTCAGGAAATCGATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCC
  CAATTCTTCTCCACGACAATGCCCGACCGCATGTTGCACAACCCACACTTCAAAAGTTGAATGAATTGGG
  CTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTTGCCAACCAACTACCACGTCTTTAAGCAT
  CTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCAAGAGTTCG
  TCGAATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGT
  TGATTGTAATGGTTCCTATTTTGATTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001243723
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001243723.1, NP_001230652.1
• RefSeq Size: 1740 bp
• RefSeq ORF: 1638 bp
• Locus ID: 6419
• Cytogenetics: 3p26.1
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Lysine degradation
• Gene Summary: 'This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]'
  Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.