LILRB4 (NM_001278429) Human Untagged Clone

CAT#: SC336361

LILRB4 (untagged) - Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LILRB4
• Synonyms: CD85K; ILT-3; ILT3; LIR-5; LIR5
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001278429, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAACAACCCCATGACGAGAAGGACCCAGCCTCCAAGCGGCCACACCCTGTGTGTCTCTTTGTCCTGC
  CGGCACTGAGGACTCATCCATCTGCACAGCTGGGGCCCCTGGGAGGAGACGCCATGATCCCCACCTTCAC
  GGCTCTGCTCTGCCTCGGGCCCCTCCCCAAACCCACCCTCTGGGCTGAGCCAGGCTCTGTGATCAGCTGG
  GGGAACTCTGTGACCATCTGGTGTCAGGGGACCCTGGAGGCTCGGGAGTACCGTCTGGATAAAGAGGAAA
  GCCCAGCACCCTGGGACAGACAGAACCCACTGGAGCCCAAGAACAAGGCCAGATTCTCCATCCCATCCAT
  GACAGAGGACTATGCAGGGAGATACCGCTGTTACTATCGCAGCCCTGTAGGCTGGTCACAGCCCAGTGAC
  CCCCTGGAGCTGGTGATGACAGGAGCCTACAGTAAACCCACCCTTTCAGCCCTGCCGAGTCCTCTTGTGA
  CCTCAGGAAAGAGCGTGACCCTGCTGTGTCAGTCACGGAGCCCAATGGACACTTTTCTTCTGATCAAGGA
  GCGGGCAGCCCATCCCCTACTGCATCTGAGATCAGAGCACGGAGCTCAGCAGCACCAGGCTGAATTCCCC
  ATGAGTCCTGTGACCTCAGTGCACGGGGGGACCTACAGGTGCTTCAGCTCACACGGCTTCTCCCACTACC
  TGCTGTCACACCCCAGTGACCCCCTGGAGCTCATAGTCTCAGGATCCTTGGAGGGTCCCAGGCCCTCACC
  CACAAGGTCCGTCTCAACAGCTGCAGGCCCTGAGGACCAGCCCCTCATGCCTACAGGGTCAGTCCCCCAC
  AGTGGTCTGAGAAGGCACTGGGAGGTACTGATCGGGGTCTTGGTGGTCTCCATCCTGCTTCTCTCCCTCC
  TCCTCTTCCTCCTCCTCCAACACTGGCGTCAGGGAAAACACAGGACATTGGCCCAGAGACAGGCTGATTT
  CCAACGTCCTCCAGGGGCTGCCGAGCCAGAGCCCAAGGACGGGGGCCTACAGAGGAGGTCCAGCCCAGCT
  GCTGACGTCCAGGGAGAAAACTTCTCAGGTGCTGCCGTGAAGAACACACAGCCTGAGGACGGGGTGGAAA
  TGGACACTCGGCAGAGCCCACACGATGAAGACCCCCAGGCAGTGACGTATGCCAAGGTGAAACACTCCAG
  ACCTAGGAGAGAAATGGCCTCTCCTCCCTCCCCACTGTCTGGGGAATTCCTGGACACAAAGGACAGACAG
  GCAGAAGAGGACAGACAGATGGACACTGAGGCTGCTGCATCTGAAGCCCCCCAGGATGTGACCTACGCCC
  GGCTGCACAGCTTTACCCTCAGACAGAAGGCAACTGAGCCTCCTCCATCCCAGGAAGGGGCCTCTCCAGC
  TGAGCCCAGTGTCTATGCCACTCTGGCCATCCACTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001278429
• ORF Size: 1437 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001278429.3, NP_001265358.2
• RefSeq Size: 3869
• RefSeq ORF: 1437
• Locus ID: 11006
• Protein Families: Transmembrane
• Gene Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (4) is longer and contains a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.