Human ALAS2 activation kit by CRISPRa

CAT#: GA100147

ALAS2 CRISPRa kit - CRISPR gene activation of human 5'-aminolevulinate synthase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALAS2
• Locus ID: 212
• Kit Components:

  GA100147G1, ALAS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100147G2, ALAS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100147G3, ALAS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000032, NM_001037967, NM_001037968, NM_001037969
• Synonyms: ALAS-E; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA
• Summary: 'The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]'