Human AARE (APEH) activation kit by CRISPRa

CAT#: GA100228

APEH CRISPRa kit - CRISPR gene activation of human acylaminoacyl-peptide hydrolase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APEH
• Locus ID: 327
• Kit Components:

  GA100228G1, AARE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100228G2, AARE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100228G3, AARE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001640
• Synonyms: AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2; OPH
• Summary: ' This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]'