Human ATIC activation kit by CRISPRa

CAT#: GA100328

ATIC CRISPRa kit - CRISPR gene activation of human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATIC
• Locus ID: 471
• Kit Components:

  GA100328G1, ATIC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100328G2, ATIC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100328G3, ATIC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004044
• Synonyms: AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
• Summary: 'This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]'