Human BMX activation kit by CRISPRa

CAT#: GA100456

BMX CRISPRa kit - CRISPR gene activation of human BMX non-receptor tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BMX
• Locus ID: 660
• Kit Components:

  GA100456G1, BMX gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100456G2, BMX gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100456G3, BMX gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320866, NM_001721, NM_203281
• Synonyms: ETK; PSCTK2; PSCTK3
• Summary: 'This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]'