Human Caspase-6 (CASP6) activation kit by CRISPRa

CAT#: GA100592

CASP6 CRISPRa kit - CRISPR gene activation of human caspase 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP6
• Locus ID: 839
• Kit Components:

  GA100592G1, Caspase-6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100592G2, Caspase-6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100592G3, Caspase-6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001226, NM_032992, NR_133012
• Synonyms: MCH2
• Summary: 'This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]'