Human CD27 activation kit by CRISPRa

CAT#: GA100661

CD27 CRISPRa kit - CRISPR gene activation of human CD27 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD27
• Locus ID: 939
• Kit Components:

  GA100661G1, CD27 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100661G2, CD27 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100661G3, CD27 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242
• Synonyms: S152; S152. LPFS2; T14; TNFRSF7; Tp55
• Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]'