Human p15 INK4b (CDKN2B) activation kit by CRISPRa

CAT#: GA100742

CDKN2B CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDKN2B
• Locus ID: 1030
• Kit Components:

  GA100742G1, p15 INK4b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100742G2, p15 INK4b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100742G3, p15 INK4b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004936, NM_078487
• Synonyms: CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
• Summary: 'This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]'