Human CHD3 activation kit by CRISPRa

CAT#: GA100789

CHD3 CRISPRa kit - CRISPR gene activation of human chromodomain helicase DNA binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHD3
• Locus ID: 1107
• Kit Components:

  GA100789G1, CHD3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100789G2, CHD3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100789G3, CHD3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005271, NM_001005273, NM_001272, NM_005852
• Synonyms: Mi-2a; Mi2-ALPHA; ZFH
• Summary: 'This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'