Human CHD4 activation kit by CRISPRa

CAT#: GA100790

CHD4 CRISPRa kit - CRISPR gene activation of human chromodomain helicase DNA binding protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHD4
• Locus ID: 1108
• Kit Components:

  GA100790G1, CHD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100790G2, CHD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100790G3, CHD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001273, NM_001297553, NM_001363606, NM_001297553.2
• Synonyms: CHD-4; Mi-2b; Mi2-BETA
• Summary: 'The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]'