Human CHIT1 activation kit by CRISPRa

CAT#: GA100798

CHIT1 CRISPRa kit - CRISPR gene activation of human chitinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHIT1
• Locus ID: 1118
• Kit Components:

  GA100798G1, CHIT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100798G2, CHIT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100798G3, CHIT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256125, NM_001270509, NM_003465, NR_045784, NR_045785
• Synonyms: CHI3; CHIT; CHITD
• Summary: 'Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]'