Human CNGB1 activation kit by CRISPRa

CAT#: GA100878

CNGB1 CRISPRa kit - CRISPR gene activation of human cyclic nucleotide gated channel subunit beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CNGB1
• Locus ID: 1258
• Kit Components:

  GA100878G1, CNGB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100878G2, CNGB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100878G3, CNGB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135639, NM_001286130, NM_001297, NM_001286130.2
• Synonyms: CNCG2; CNCG3L; CNCG4; CNG4; CNGB1B; GAR1; GARP; GARP2; RCNC2; RCNCb; RCNCbeta; RP45
• Summary: 'In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]'