Human Collagen II (COL2A1) activation kit by CRISPRa

CAT#: GA100895

COL2A1 CRISPRa kit - CRISPR gene activation of human collagen type II alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL2A1
• Locus ID: 1280
• Kit Components:

  GA100895G1, Collagen II gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100895G2, Collagen II gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100895G3, Collagen II gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001844, NM_033150
• Synonyms: ANFH; AOM; COL11A3; SEDC; STL1
• Summary: 'This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]'