Human Collagen X (COL10A1) activation kit by CRISPRa

CAT#: GA100914

COL10A1 CRISPRa kit - CRISPR gene activation of human collagen type X alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL10A1
• Locus ID: 1300
• Kit Components:

  GA100914G1, Collagen X gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100914G2, Collagen X gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100914G3, Collagen X gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000493
• Synonyms: collagen, type X, alpha 1; collagen X, alpha-1 polypeptide; OTTHUMP00000017049; OTTHUMP00000040411; Schmid metaphyseal chondrodysplasia; type X collagen alpha 1
• Summary: 'This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]'