Human Cathepsin D (CTSD) activation kit by CRISPRa

CAT#: GA101067

CTSD CRISPRa kit - CRISPR gene activation of human cathepsin D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTSD
• Locus ID: 1509
• Kit Components:

  GA101067G1, Cathepsin D gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101067G2, Cathepsin D gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101067G3, Cathepsin D gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001909
• Synonyms: CLN10; CPSD; HEL-S-130P
• Summary: 'This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]'