Human Cathepsin K (CTSK) activation kit by CRISPRa

CAT#: GA101071

CTSK CRISPRa kit - CRISPR gene activation of human cathepsin K

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTSK
• Locus ID: 1513
• Kit Components:

  GA101071G1, Cathepsin K gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101071G2, Cathepsin K gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101071G3, Cathepsin K gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000396
• Synonyms: CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD
• Summary: 'The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]'