Human Dystrobrevin beta (DTNB) activation kit by CRISPRa

CAT#: GA101288

DTNB CRISPRa kit - CRISPR gene activation of human dystrobrevin beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DTNB
• Locus ID: 1838
• Kit Components:

  GA101288G1, Dystrobrevin beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101288G2, Dystrobrevin beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101288G3, Dystrobrevin beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256303, NM_001256304, NM_001256308, NM_021907, NM_033147, NM_033148, NM_183360, NM_183361, NM_001320932, NM_001320933, NM_001320934, NM_001320935, NM_001320936, NM_001320937, NM_001351381, NM_001351382, NM_001351383, NM_001351384, NM_001351385, NM_001351386, NM_001351387, NM_001351388, NM_001351389, NM_001351390, NM_001351391, NM_001351392, NM_001351393, NM_001351394, NM_001351395, NR_147180
• Summary: 'This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]'