Human Endothelin A Receptor (EDNRA) activation kit by CRISPRa

CAT#: GA101330

EDNRA CRISPRa kit - CRISPR gene activation of human endothelin receptor type A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EDNRA
• Locus ID: 1909
• Kit Components:

  GA101330G1, Endothelin A Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101330G2, Endothelin A Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101330G3, Endothelin A Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166055, NM_001256283, NM_001957, NR_028596, NR_045958, NM_001354797, NR_148963, NR_148964
• Synonyms: ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR
• Summary: 'This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]'