Human EZH2 activation kit by CRISPRa

CAT#: GA101494

EZH2 CRISPRa kit - CRISPR gene activation of human enhancer of zeste 2 polycomb repressive complex 2 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EZH2
• Locus ID: 2146
• Kit Components:

  GA101494G1, EZH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101494G2, EZH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101494G3, EZH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001203247, NM_001203248, NM_001203249, NM_004456, NM_152998
• Synonyms: ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2
• Summary: 'This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]'