Human FDPS activation kit by CRISPRa

CAT#: GA101558

FDPS CRISPRa kit - CRISPR gene activation of human farnesyl diphosphate synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FDPS
• Locus ID: 2224
• Kit Components:

  GA101558G1, FDPS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101558G2, FDPS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101558G3, FDPS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135821, NM_001135822, NM_001242824, NM_001242825, NM_002004
• Synonyms: FPPS; FPS; POROK9
• Summary: 'This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]'