Human VEGF Receptor 1 (FLT1) activation kit by CRISPRa

CAT#: GA101629

FLT1 CRISPRa kit - CRISPR gene activation of human fms related tyrosine kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FLT1
• Locus ID: 2321
• Kit Components:

  GA101629G1, VEGF Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101629G2, VEGF Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101629G3, VEGF Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001159920, NM_001160030, NM_001160031, NM_002019
• Synonyms: FLT; FLT-1; VEGFR-1; VEGFR1
• Summary: 'This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]'