Human FOLR2 activation kit by CRISPRa

CAT#: GA101646

FOLR2 CRISPRa kit - CRISPR gene activation of human folate receptor beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FOLR2
• Locus ID: 2350
• Kit Components:

  GA101646G1, FOLR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101646G2, FOLR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101646G3, FOLR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000803, NM_001113534, NM_001113535, NM_001113536
• Synonyms: BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3
• Summary: 'The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'