Human GAD67 (GAD1) activation kit by CRISPRa

CAT#: GA101714

GAD1 CRISPRa kit - CRISPR gene activation of human glutamate decarboxylase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GAD1
• Locus ID: 2571
• Kit Components:

  GA101714G1, GAD67 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101714G2, GAD67 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101714G3, GAD67 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000817, NM_013445
• Synonyms: CPSQ1; GAD; SCP
• Summary: 'This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]'