Human GAD65 (GAD2) activation kit by CRISPRa

CAT#: GA101715

GAD2 CRISPRa kit - CRISPR gene activation of human glutamate decarboxylase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GAD2
• Locus ID: 2572
• Kit Components:

  GA101715G1, GAD65 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101715G2, GAD65 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101715G3, GAD65 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000818, NM_001134366
• Synonyms: GAD65
• Summary: 'This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]'