Human CD42a (GP9) activation kit by CRISPRa

CAT#: GA101882

GP9 CRISPRa kit - CRISPR gene activation of human glycoprotein IX platelet

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GP9
• Locus ID: 2815
• Kit Components:

  GA101882G1, CD42a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101882G2, CD42a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101882G3, CD42a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000174
• Synonyms: CD42a; GPIX
• Summary: 'This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]'