Human Alanine Transaminase (GPT) activation kit by CRISPRa

CAT#: GA101934

GPT CRISPRa kit - CRISPR gene activation of human glutamic--pyruvic transaminase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GPT
• Locus ID: 2875
• Kit Components:

  GA101934G1, GPT gRNA vector 1 in pCas-Guide-CRISPRa

  GA101934G2, GPT gRNA vector 2 in pCas-Guide-CRISPRa

  GA101934G3, GPT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005309
• Synonyms: AAT1; ALT1; GPT1
• Summary: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. [provided by RefSeq, Nov 2009]