Human HDAC2 activation kit by CRISPRa

CAT#: GA102089

HDAC2 CRISPRa kit - CRISPR gene activation of human histone deacetylase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HDAC2
• Locus ID: 3066
• Kit Components:

  GA102089G1, HDAC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102089G2, HDAC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102089G3, HDAC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001527, NR_033441, NR_073443
• Synonyms: HD2; RPD3; YAF1
• Summary: 'This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]'