Human HPS1 activation kit by CRISPRa

CAT#: GA102229

HPS1 CRISPRa kit - CRISPR gene activation of human HPS1 biogenesis of lysosomal organelles complex 3 subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HPS1
• Locus ID: 3257
• Kit Components:

  GA102229G1, HPS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102229G2, HPS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102229G3, HPS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000195, NM_182637, NM_182638, NM_182639, NM_001311345, NM_001322476, NM_001322477, NM_001322478, NM_001322479, NM_001322480, NM_001322481, NM_001322482, NM_001322483, NM_001322484, NM_001322485, NM_001322487, NM_001322489, NM_001322490, NM_001322491, NM_001322492
• Synonyms: HPS
• Summary: 'This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 1. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on chromosome 22. [provided by RefSeq, Aug 2015]'