Human HSF4 activation kit by CRISPRa

CAT#: GA102253

HSF4 CRISPRa kit - CRISPR gene activation of human heat shock transcription factor 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HSF4
• Locus ID: 3299
• Kit Components:

  GA102253G1, HSF4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102253G2, HSF4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102253G3, HSF4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040667, NM_001538
• Synonyms: CTM; CTRCT5
• Summary: 'Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]'