Human HTR2B activation kit by CRISPRa

CAT#: GA102285

HTR2B CRISPRa kit - CRISPR gene activation of human 5-hydroxytryptamine receptor 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HTR2B
• Locus ID: 3357
• Kit Components:

  GA102285G1, HTR2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102285G2, HTR2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102285G3, HTR2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000867, NM_001320758
• Synonyms: 5-HT(2B); 5-HT2B
• Summary: 'This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]'