Human IGF2R activation kit by CRISPRa

CAT#: GA102351

IGF2R CRISPRa kit - CRISPR gene activation of human insulin like growth factor 2 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IGF2R
• Locus ID: 3482
• Kit Components:

  GA102351G1, IGF2R gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102351G2, IGF2R gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102351G3, IGF2R gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000876
• Synonyms: CD222; CIMPR; M6P-R; MPR1; MPRI
• Summary: 'This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]'