Human IL11 activation kit by CRISPRa

CAT#: GA102399

IL11 CRISPRa kit - CRISPR gene activation of human interleukin 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL11
• Locus ID: 3589
• Kit Components:

  GA102399G1, IL11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102399G2, IL11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102399G3, IL11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000641, NM_001267718
• Synonyms: AGIF; IL-11
• Summary: 'The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]'