Human IL16 activation kit by CRISPRa

CAT#: GA102410

IL16 CRISPRa kit - CRISPR gene activation of human interleukin 16

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL16
• Locus ID: 3603
• Kit Components:

  GA102410G1, IL16 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102410G2, IL16 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102410G3, IL16 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172128, NM_004513, NM_172217, NM_001352684, NM_001352685, NM_001352686, NR_148035
• Synonyms: LCF; NIL16; prIL-16; PRIL16
• Summary: 'The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]'