Human Integrin alpha 6 (ITGA6) activation kit by CRISPRa

CAT#: GA102449

ITGA6 CRISPRa kit - CRISPR gene activation of human integrin subunit alpha 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGA6
• Locus ID: 3655
• Kit Components:

  GA102449G1, Integrin alpha 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102449G2, Integrin alpha 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102449G3, Integrin alpha 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000210, NM_001079818, NM_001316306, NM_001365529, NM_001365530
• Synonyms: CD49f; ITGA6B; VLA-6
• Summary: 'The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]'