Human Islet 1 (ISL1) activation kit by CRISPRa

CAT#: GA102461

ISL1 CRISPRa kit - CRISPR gene activation of human ISL LIM homeobox 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ISL1
• Locus ID: 3670
• Kit Components:

  GA102461G1, Islet 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102461G2, Islet 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102461G3, Islet 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002202
• Synonyms: Isl-1; ISLET1
• Summary: 'This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]'