Human CD11a (ITGAL) activation kit by CRISPRa

CAT#: GA102473

ITGAL CRISPRa kit - CRISPR gene activation of human integrin subunit alpha L

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGAL
• Locus ID: 3683
• Kit Components:

  GA102473G1, CD11a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102473G2, CD11a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102473G3, CD11a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114380, NM_002209
• Synonyms: CD11A; LFA-1; LFA1A
• Summary: 'ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'