Human KCNN1 activation kit by CRISPRa

CAT#: GA102554

KCNN1 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily N member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNN1
• Locus ID: 3780
• Kit Components:

  GA102554G1, KCNN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102554G2, KCNN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102554G3, KCNN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002248
• Synonyms: hSK1; KCa2.1; SK1; SKCA1
• Summary: 'Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]'