Human KCNN3 activation kit by CRISPRa

CAT#: GA102556

KCNN3 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily N member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNN3
• Locus ID: 3782
• Kit Components:

  GA102556G1, KCNN3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102556G2, KCNN3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102556G3, KCNN3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204087, NM_002249, NM_170782, NM_001365838, NM_001365837
• Synonyms: hSK3; KCa2.3; SK3; SKCA3
• Summary: 'Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]'