Human KPNA5 activation kit by CRISPRa

CAT#: GA102605

KPNA5 CRISPRa kit - CRISPR gene activation of human karyopherin subunit alpha 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KPNA5
• Locus ID: 3841
• Kit Components:

  GA102605G1, KPNA5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102605G2, KPNA5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102605G3, KPNA5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002269, NM_001366305, NM_001366306, NM_001366308, NM_001366304, NM_001366307, NM_001366309, NM_001366310
• Synonyms: IPOA6; SRP6
• Summary: 'The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]'