Human MDH2 activation kit by CRISPRa

CAT#: GA102856

MDH2 CRISPRa kit - CRISPR gene activation of human malate dehydrogenase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MDH2
• Locus ID: 4191
• Kit Components:

  GA102856G1, MDH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102856G2, MDH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102856G3, MDH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282403, NM_001282404, NM_005918, NR_104165
• Synonyms: M-MDH; MDH; MGC:3559; MOR1
• Summary: 'Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]'