Human MUC2 activation kit by CRISPRa

CAT#: GA103033

MUC2 CRISPRa kit - CRISPR gene activation of human mucin 2, oligomeric mucus/gel-forming

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MUC2
• Locus ID: 4583
• Kit Components:

  GA103033G1, MUC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA103033G2, MUC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA103033G3, MUC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002457
• Synonyms: MLP; MUC-2; SMUC
• Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]