Human NAGLU activation kit by CRISPRa

CAT#: GA103102

NAGLU CRISPRa kit - CRISPR gene activation of human N-acetyl-alpha-glucosaminidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NAGLU
• Locus ID: 4669
• Kit Components:

  GA103102G1, NAGLU gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103102G2, NAGLU gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103102G3, NAGLU gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000263
• Synonyms: MPS-IIIB; MPS3B; NAG; UFHSD
• Summary: 'This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]'