Human ANP (NPPA) activation kit by CRISPRa

CAT#: GA103255

NPPA CRISPRa kit - CRISPR gene activation of human natriuretic peptide A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPPA
• Locus ID: 4878
• Kit Components:

  GA103255G1, ANP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103255G2, ANP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103255G3, ANP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006172
• Synonyms: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; PND
• Summary: 'The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]'