Human Oligodendrocyte Specific Protein (CLDN11) activation kit by CRISPRa

CAT#: GA103343

CLDN11 CRISPRa kit - CRISPR gene activation of human claudin 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLDN11
• Locus ID: 5010
• Kit Components:

  GA103343G1, Oligodendrocyte Specific Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103343G2, Oligodendrocyte Specific Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103343G3, Oligodendrocyte Specific Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185056, NM_005602
• Synonyms: OSP; OTM
• Summary: 'This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]'