Human PDZK1 activation kit by CRISPRa

CAT#: GA103470

PDZK1 CRISPRa kit - CRISPR gene activation of human PDZ domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDZK1
• Locus ID: 5174
• Kit Components:

  GA103470G1, PDZK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103470G2, PDZK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103470G3, PDZK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201325, NM_001201326, NM_002614
• Synonyms: CAP70; CLAMP; NHERF-3; NHERF3; PDZD1
• Summary: 'This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]'