Human PEDF (SERPINF1) activation kit by CRISPRa

CAT#: GA103472

SERPINF1 CRISPRa kit - CRISPR gene activation of human serpin family F member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPINF1
• Locus ID: 5176
• Kit Components:

  GA103472G1, PEDF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103472G2, PEDF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103472G3, PEDF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329903, NM_001329904, NM_001329905, NM_002615
• Synonyms: EPC-1; OI6; OI12; PEDF; PIG35
• Summary: 'This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]'