Human PGGT1B activation kit by CRISPRa

CAT#: GA103514

PGGT1B CRISPRa kit - CRISPR gene activation of human protein geranylgeranyltransferase type I subunit beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGGT1B
• Locus ID: 5229
• Kit Components:

  GA103514G1, PGGT1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103514G2, PGGT1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103514G3, PGGT1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005023
• Synonyms: BGGI; GGTI
• Summary: 'Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]'