Human PPM1B activation kit by CRISPRa

CAT#: GA103701

PPM1B CRISPRa kit - CRISPR gene activation of human protein phosphatase, Mg2+/Mn2+ dependent 1B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPM1B
• Locus ID: 5495
• Kit Components:

  GA103701G1, PPM1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103701G2, PPM1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103701G3, PPM1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033556, NM_001033557, NM_002706, NM_177968, NM_177969
• Synonyms: PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
• Summary: 'The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]'